Cancer-miRNA Regulatory Network

Compendium of miRNA Target Genes

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MPM Mesothelioma Gordon Cluster Number 44 (142 genes) This page contains all miRNA mediated regulation and functional enrichment for MPM Mesothelioma Gordon cluster number 44. Information about mesothelioma can be found on Wikipedia, and further information about the "MPM Mesothelioma Gordon" dataset can be found in Gordon et al., 2005. Inferred miRNA Mediated Regulation Weeder-miRvestigator PITA TargetScan zzz999 zzz999 hsa-mir-338-5p Gene Ontology Enrichment GO ID GO Term Annotated Genes in Cluster GO:0000075 cell cycle checkpoint 15 GO:0000077 DNA damage checkpoint 13 GO:0000082 G1/S transition of mitotic cell cycle 10 GO:0000084 S phase of mitotic cell cycle 10 GO:0000216 M/G1 transition of mitotic cell cycle 10 GO:0000278 mitotic cell cycle 19 GO:0006082 organic acid metabolic process 17 GO:0006119 oxidative phosphorylation 5 GO:0006120 mitochondrial electron transport, NADH to ubiquinone 4 GO:0006511 ubiquitin-dependent protein catabolic process 14 GO:0006520 cellular amino acid metabolic process 14 GO:0006521 regulation of cellular amino acid metabolic process 10 GO:0006974 response to DNA damage stimulus 24 GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest 10 GO:0007049 cell cycle 24 GO:0007093 mitotic cell cycle checkpoint 12 GO:0007346 regulation of mitotic cell cycle 12 GO:0009057 macromolecule catabolic process 16 GO:0009308 amine metabolic process 15 GO:0010498 proteasomal protein catabolic process 12 GO:0016032 viral reproduction 17 GO:0016071 mRNA metabolic process 18 GO:0019538 protein metabolic process 46 GO:0019752 carboxylic acid metabolic process 17 GO:0019941 modification-dependent protein catabolic process 14 GO:0022402 cell cycle process 22 GO:0022403 cell cycle phase 20 GO:0022900 electron transport chain 7 GO:0022904 respiratory electron transport chain 7 GO:0030163 protein catabolic process 14 GO:0030330 DNA damage response, signal transduction by p53 class mediator 10 GO:0031145 anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process 11 GO:0031570 DNA integrity checkpoint 13 GO:0031571 mitotic cell cycle G1/S transition DNA damage checkpoint 10 GO:0031575 mitotic cell cycle G1/S transition checkpoint 10 GO:0033238 regulation of cellular amine metabolic process 11 GO:0033554 cellular response to stress 25 GO:0042770 signal transduction in response to DNA damage 11 GO:0042773 ATP synthesis coupled electron transport 5 GO:0042775 mitochondrial ATP synthesis coupled electron transport 5 GO:0043086 negative regulation of catalytic activity 12 GO:0043161 proteasomal ubiquitin-dependent protein catabolic process 12 GO:0043632 modification-dependent macromolecule catabolic process 14 GO:0044237 cellular metabolic process 88 GO:0044257 cellular protein catabolic process 14 GO:0044265 cellular macromolecule catabolic process 16 GO:0044267 cellular protein metabolic process 44 GO:0051276 chromosome organization 15 GO:0051320 S phase 11 GO:0051325 interphase 16 GO:0051329 interphase of mitotic cell cycle 15 GO:0051340 regulation of ligase activity 11 GO:0051351 positive regulation of ligase activity 11 GO:0051352 negative regulation of ligase activity 11 GO:0051436 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle 11 GO:0051437 positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle 11 GO:0051438 regulation of ubiquitin-protein ligase activity 11 GO:0051439 regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle 11 GO:0051443 positive regulation of ubiquitin-protein ligase activity 11 GO:0051444 negative regulation of ubiquitin-protein ligase activity 11 GO:0051603 proteolysis involved in cellular protein catabolic process 14 GO:0051726 regulation of cell cycle 15 Overlap Between miRNA Target Genes and Enriched Gene Ontology Annotations miRNA Method GO ID GO Term Overlap GO Annotated Genes Cluster Size miRNA Targets Genes P-Value hsa-mir-338-5p TargetScan GO:0000075 cell cycle checkpoint 4 15 142 44 0.5224823 hsa-mir-338-5p TargetScan GO:0000077 DNA damage checkpoint 3 13 142 44 0.6177599 hsa-mir-338-5p TargetScan GO:0000082 G1/S transition of mitotic cell cycle 1 10 142 44 0.8746709 hsa-mir-338-5p TargetScan GO:0000084 S phase of mitotic cell cycle 1 10 142 44 0.8746709 hsa-mir-338-5p TargetScan GO:0000216 M/G1 transition of mitotic cell cycle 1 10 142 44 0.8746709 hsa-mir-338-5p TargetScan GO:0000278 mitotic cell cycle 3 19 142 44 0.9020429 hsa-mir-338-5p TargetScan GO:0006082 organic acid metabolic process 2 17 142 44 0.9455612 hsa-mir-338-5p TargetScan GO:0006119 oxidative phosphorylation 0 5 142 44 0.8484377 hsa-mir-338-5p TargetScan GO:0006120 mitochondrial electron transport, NADH to ubiquinone 0 4 142 44 0.7774937 hsa-mir-338-5p TargetScan GO:0006511 ubiquitin-dependent protein catabolic process 3 14 142 44 0.6855128 hsa-mir-338-5p TargetScan GO:0006520 cellular amino acid metabolic process 1 14 142 44 0.9664397 hsa-mir-338-5p TargetScan GO:0006521 regulation of cellular amino acid metabolic process 1 10 142 44 0.8746709 hsa-mir-338-5p TargetScan GO:0006974 response to DNA damage stimulus 6 24 142 44 0.6684316 hsa-mir-338-5p TargetScan GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest 1 10 142 44 0.8746709 hsa-mir-338-5p TargetScan GO:0007049 cell cycle 7 24 142 44 0.4795137 hsa-mir-338-5p TargetScan GO:0007093 mitotic cell cycle checkpoint 2 12 142 44 0.7817398 hsa-mir-338-5p TargetScan GO:0007346 regulation of mitotic cell cycle 2 12 142 44 0.7817398 hsa-mir-338-5p TargetScan GO:0009057 macromolecule catabolic process 5 16 142 44 0.3684378 hsa-mir-338-5p TargetScan GO:0009308 amine metabolic process 2 15 142 44 0.9020434 hsa-mir-338-5p TargetScan GO:0010498 proteasomal protein catabolic process 2 12 142 44 0.7817398 hsa-mir-338-5p TargetScan GO:0016032 viral reproduction 3 17 142 44 0.8382062 hsa-mir-338-5p TargetScan GO:0016071 mRNA metabolic process 4 18 142 44 0.7149626 hsa-mir-338-5p TargetScan GO:0019538 protein metabolic process 16 46 142 44 0.1913175 hsa-mir-338-5p TargetScan GO:0019752 carboxylic acid metabolic process 2 17 142 44 0.9455612 hsa-mir-338-5p TargetScan GO:0019941 modification-dependent protein catabolic process 3 14 142 44 0.6855128 hsa-mir-338-5p TargetScan GO:0022402 cell cycle process 5 22 142 44 0.7408699 hsa-mir-338-5p TargetScan GO:0022403 cell cycle phase 3 20 142 44 0.9249802 hsa-mir-338-5p TargetScan GO:0022900 electron transport chain 0 7 142 44 0.9304011 hsa-mir-338-5p TargetScan GO:0022904 respiratory electron transport chain 0 7 142 44 0.9304011 hsa-mir-338-5p TargetScan GO:0030163 protein catabolic process 3 14 142 44 0.6855128 hsa-mir-338-5p TargetScan GO:0030330 DNA damage response, signal transduction by p53 class mediator 1 10 142 44 0.8746709 hsa-mir-338-5p TargetScan GO:0031145 anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process 2 11 142 44 0.7218595 hsa-mir-338-5p TargetScan GO:0031570 DNA integrity checkpoint 3 13 142 44 0.6177599 hsa-mir-338-5p TargetScan GO:0031571 mitotic cell cycle G1/S transition DNA damage checkpoint 1 10 142 44 0.8746709 hsa-mir-338-5p TargetScan GO:0031575 mitotic cell cycle G1/S transition checkpoint 1 10 142 44 0.8746709 hsa-mir-338-5p TargetScan GO:0033238 regulation of cellular amine metabolic process 2 11 142 44 0.7218595 hsa-mir-338-5p TargetScan GO:0033554 cellular response to stress 7 25 142 44 0.5387507 hsa-mir-338-5p TargetScan GO:0042770 signal transduction in response to DNA damage 1 11 142 44 0.908629 hsa-mir-338-5p TargetScan GO:0042773 ATP synthesis coupled electron transport 0 5 142 44 0.8484377 hsa-mir-338-5p TargetScan GO:0042775 mitochondrial ATP synthesis coupled electron transport 0 5 142 44 0.8484377 hsa-mir-338-5p TargetScan GO:0043086 negative regulation of catalytic activity 2 12 142 44 0.7817398 hsa-mir-338-5p TargetScan GO:0043161 proteasomal ubiquitin-dependent protein catabolic process 2 12 142 44 0.7817398 hsa-mir-338-5p TargetScan GO:0043632 modification-dependent macromolecule catabolic process 3 14 142 44 0.6855128 hsa-mir-338-5p TargetScan GO:0044237 cellular metabolic process 29 88 142 44 0.2026007 hsa-mir-338-5p TargetScan GO:0044257 cellular protein catabolic process 3 14 142 44 0.6855128 hsa-mir-338-5p TargetScan GO:0044265 cellular macromolecule catabolic process 5 16 142 44 0.3684378 hsa-mir-338-5p TargetScan GO:0044267 cellular protein metabolic process 14 44 142 44 0.3639313 hsa-mir-338-5p TargetScan GO:0051276 chromosome organization 6 15 142 44 0.1378036 hsa-mir-338-5p TargetScan GO:0051320 S phase 1 11 142 44 0.908629 hsa-mir-338-5p TargetScan GO:0051325 interphase 2 16 142 44 0.9266162 hsa-mir-338-5p TargetScan GO:0051329 interphase of mitotic cell cycle 2 15 142 44 0.9020434 hsa-mir-338-5p TargetScan GO:0051340 regulation of ligase activity 2 11 142 44 0.7218595 hsa-mir-338-5p TargetScan GO:0051351 positive regulation of ligase activity 2 11 142 44 0.7218595 hsa-mir-338-5p TargetScan GO:0051352 negative regulation of ligase activity 2 11 142 44 0.7218595 hsa-mir-338-5p TargetScan GO:0051436 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle 2 11 142 44 0.7218595 hsa-mir-338-5p TargetScan GO:0051437 positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle 2 11 142 44 0.7218595 hsa-mir-338-5p TargetScan GO:0051438 regulation of ubiquitin-protein ligase activity 2 11 142 44 0.7218595 hsa-mir-338-5p TargetScan GO:0051439 regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle 2 11 142 44 0.7218595 hsa-mir-338-5p TargetScan GO:0051443 positive regulation of ubiquitin-protein ligase activity 2 11 142 44 0.7218595 hsa-mir-338-5p TargetScan GO:0051444 negative regulation of ubiquitin-protein ligase activity 2 11 142 44 0.7218595 hsa-mir-338-5p TargetScan GO:0051603 proteolysis involved in cellular protein catabolic process 3 14 142 44 0.6855128 hsa-mir-338-5p TargetScan GO:0051726 regulation of cell cycle 4 15 142 44 0.5224823

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